Carlisle is bordered by Orrong Road to the north, Briggs/Planet/Kew streets to the east, Rutland Avenue and the Armadale Rail line to the south, and Roberts Road to the west.

Most of the streets in Carlisle are tree-lined and form the traditional grid formation of the early planning style of Perth.

The suburb is mainly flat with the eastern boundary offering views of the city. The Weston Street/Archer Street intersection is the highest point in the west end of the suburb.

 The Perth-Armadale rail line runs through this area and the suburb is serviced by the Carlisle Train Station and the Oats Street Train Station.

There are 4 parks, Fletcher Park, Carlisle Reserve, Parnham Park and Tom Wright Park.

The Carlisle Hotel and TAB are opposite Carlisle Train station. Other facilities include the Carlisle Lathlain Bowling Club, Holy Name Primary School, Lathlain Nursing Home, Windsor Park Nursing Home, Harold Hawthorne Seniors Centre, Town of Victoria Park Council Depot, and the Belmont City Works Depot.